During endodontic treatment in multi-rooted teeth, furcation perforation refers to an opening in the pulpal floor, leading to a communication with the periodontal ligament space. A three-dimensional hermetic seal, with a biocompatible material, is a key point for the success of pulp floor perforation repair. MTA® has been considered, for a long time, as a gold standard in furcation perforation repair. Besides, BiodentineTM, when used for the same purpose, showed considerable performance and good results. The purpose of this paper was to report the management of an iatrogenic perforation of pulpal floor in the maxillary right first molar, using BiodentineTM.