Sickle cell anemia and its impact on the oral cavity: integrative review
English | Français USJ Journals | Editions de l'USJ
Vol 16 No 2 (2025), Meta-Analysis
Vol 16 No 2 (2025)

Sickle cell anemia and its impact on the oral cavity: integrative review

Meta-Analysis
Published 14 October 2025
Fernanda LEAL
RISE-Health, Faculty of Health Sciences, Fernando Pessoa University, Fernando Pessoa Teaching and Culture Foundation, Rua Carlos da Maia 296, 4200-150 Porto, Portugal.
Maria Inês GUIMARÃES
RISE-Health, Faculty of Health Sciences, Fernando Pessoa University, FP-I3ID, FP-BHS, Fernando Pessoa Teaching and Culture Foundation, Rua Carlos da Maia 296, 4200-150 Porto, Portugal; INMLCF, I. P., North Delegation - National Institute of Legal Medicine and Forensic Sciences, I. P., Jardim Carrilho Videira 4050-167 Porto, Portugal and CEISUC, Centre of Investigation in Technologies and Centre for Health Studies and Research of the University of Coimbra, 3004-512 Coimbra, Portugal.
Ambre NATBETH
FCS-UFP, Health Sciences Faculty, University Fernando Pessoa, 4249-004 Porto, Portugal.
Inês LOPES CARDOSO
RISE-Health, Faculty of Health Sciences, Fernando Pessoa University, EMCB-UFP, FP-I3ID and FP-BHS, Fernando Pessoa Teaching and Culture Foundation, Rua Carlos da Maia 296, 4200-150 Porto, Portugal.
PDF

Keywords

Sickle cell disease
Oral manifestations
Dental treatments
Oral health
Correlation

How to Cite

LEAL, F., GUIMARÃES, M. I., NATBETH, A., & LOPES CARDOSO, I. (2025). Sickle cell anemia and its impact on the oral cavity: integrative review. International Arab Journal of Dentistry (IAJD), 16(2), 146-158. Retrieved from https://journals.usj.edu.lb/iajd/article/view/1491
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver

Download Citation

Endnote/Zotero/Mendeley (RIS) BibTeX

Abstract

Introduction: Sickle cell anemia, a hereditary disease, results from a mutation in the β-globin coding gene that makes up hemoglobin, leading to the deformation of erythrocytes. Numerous oral manifestations result from this disease; however, some may not be specific.

Objectives: This study’s objective is to recognize these clinical manifestations of the disease to be able to manage oral health in sickle cell anemia patients.

Methods: This integrative review analyzes scientific literature on the impact of sickle cell anemia on the oral cavity. A bibliographic search was performed in PubMed, ScienceDirect, CINAHL Plus (via EBSCO host), Web of Science and Google Scholar databases using several combined keywords. The research question was: “What is the impact of sickle cell anemia on the oral cavity and dental treatments?”.

Results: By applying the inclusion and exclusion criteria, 11 articles were included in this review.

Conclusions: Studies show that the most common oral manifestations in these patients are periodontal disease and caries, although this association is not well understood.

PDF